Researchers have discovered a mechanism in adult stem cells by which the cells suppress their ability to initiate cancer during their dormant phase, an understanding that could be exploited for better cancer prevention strategies.
The study, conducted at UCLA’s Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, was led by Andrew White, post-doctoral fellow, and William Lowry, associate professor of molecular.
Hair follicle stem cells (HFSC), the tissue-specific adult stem cells that generate the hair follicles, are also the cells of origin for cutaneous squamous cell carcinoma (SCC), a common skin cancer. These HFSCs cycle between periods of activation, during which they can grow, and quiescence, when they remain dormant.
Using mouse models, White and Lowry applied known cancer-causing genes (oncogenes) to HFSCs and found that during cell quiescence, the cells could not be made to initiate SCC. Once the HFSC were in their active period, they began growing cancer.
“We found that this tumor suppression via adult stem cell quiescence was mediated by Pten, a gene important in regulating the cell’s response to signaling pathways,” White said, “therefore, stem cell quiescence is a novel form of tumor suppression in hair follicle stem cells, and Pten must be present for the suppression to work.”
Source: Nature Cell Biology